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Article

Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem.

Archives of pharmacal research - 1 Aug 2018

Byeon Ji-Yeong, Kim Young-Hoon, Kim Se-Hyung, Lee Choong-Min, Jung Eui-Hyun, Chae Won-Ki, Jang Choon-Gon, Lee Seok-Yong, Lee Yun Jeong

Abstract excerpt

Zolpidem is indicated for the short-term treatment of insomnia and it is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C19, CYP1A2, and CYP2C9. Therefore, we evaluated the effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of zolpidem in healthy male subjects. Thirty-two male subjects were recruited and all subjects were classified into three groups according to their genotypes:...

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Identifiers

PMID: 30117082
DOI: 10.1007/s12272-018-1065-8

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