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Article

Optimization of Clonazepam Therapy Adjusted to Patient’s CYP3A Status andNAT2Genotype

17 Sept 2016

Abstract excerpt

BACKGROUND: The shortcomings of clonazepam therapy include tolerance, withdrawal symptoms, and adverse effects such as drowsiness, dizziness, and confusion leading to increased risk of falls. Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors. METHODS: Since the prominent role in...

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PMID: 27639091
DOI: 10.1093/ijnp/pyw083

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