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Article

Contrasting the impact of cytotoxic and cytostatic drug therapies on tumour progression.

PLoS computational biology - 1 Nov 2019

Anttila Jani V, Shubin Mikhail, Cairns Johannes, Borse Florian, Guo Qingli, Mononen Tommi, Vázquez-García Ignacio, Pulkkinen Otto, Mustonen Ville

Abstract excerpt

A tumour grows when the total division (birth) rate of its cells exceeds their total mortality (death) rate. The capability for uncontrolled growth within the host tissue is acquired via the accumulation of driver mutations which enable the tumour to progress through various hallmarks of cancer. We present a mathematical model of the penultimate stage in such a progression. We assume the tumour has reached the...

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Identifiers

PMID: 31738747
DOI: 10.1371/journal.pcbi.1007493
PMCID: PMC6886869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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