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Article

Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot.

Pediatric research - 1 Jul 2020

Kozyrev Ivan, Dokshin Pavel, Kostina Aleksandra, Kiselev Artem, Ignatieva Elena, Golovkin Alexey, Pervunina Tatiana, Grekhov Evgeny, Gordeev Mikhail, Kostareva Anna, Malashicheva Anna

Abstract excerpt

BACKGROUND: Tetralogy of Fallot (TF) is a severe congenital defect of heart development. Fine-tuned sequential activation of Notch signaling genes is responsible for proper heart chamber development. Mutations in Notch genes have been associated with TF. The aim of this study was to analyze the activity of the Notch pathway in cardiac mesenchymal cells derived from ventricular tissue of TF patients. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31952074
DOI: 10.1038/s41390-020-0760-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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