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Article

Silencing mutations in JAG1 gene may play crucial roles in the pathogenesis of Tetralogy of Fallot.

Cellular and molecular biology (Noisy-le-Grand, France) - 31 Mar 2018

Safari-Arababadi Amin, Behjati-Ardakani Mostafa, Kalantar Seyed Mehdi, Jaafarinia Mojtaba

Abstract excerpt

JAG1 gene through Notch signaling is implicated in cell fate decisions in early cardiac development, and mutations in several proteins in the pathway have been involved in various disorders. Tetralogy of Fallot (TOF) is the most frequent form of complicated congenital heart disease. The abnormality of TOF begins through the first eight weeks of fetal growth and is confused with ventricular septal defects,...

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PMID: 29631691

Genes

JAG1

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