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Article

Role of Notch signaling in the mammalian heart

12 Dec 2013

Abstract excerpt

Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair...

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PMID: 24345875
DOI: 10.1590/1414-431x20133177

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