Article
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing.
Scientific reports - 16 Jan 2020
Nemtsova Marina V, Kalinkin Alexey I, Kuznetsova Ekaterina B, Bure Irina V, Alekseeva Ekaterina A, Bykov Igor I, Khorobrykh Tatiana V, Mikhaylenko Dmitry S, Tanas Alexander S, Kutsev Sergey I, Zaletaev Dmitry V, Strelnikov Vladimir V
Abstract excerpt
Somatic mutation profiling in gastric cancer (GC) enables main driver mutations to be identified and their clinical and prognostic value to be evaluated. We investigated 77 tumour samples of GC by next-generation sequencing (NGS) with the Ion AmpliSeq Hotspot Panel v2 and a custom panel covering six hereditary gastric cancer predisposition genes (BMPR1A, SMAD4, CDH1, TP53, STK11 and PTEN). Overall, 47 somatic...
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