Article
Salpingectomy With Delayed Oophorectomy in BRCA1/2 Mutation Carriers: Estimating Ovarian Cancer Risk.
Obstetrics and gynecology - 1 Jun 2016
Harmsen Marline G, IntHout Joanna, Arts-de Jong Marieke, Hoogerbrugge Nicoline, Massuger Leon F A G, Hermens Rosella P M G, de Hullu Joanne A
Abstract excerpt
OBJECTIVE: To estimate BRCA1/2 mutation carriers' cumulative ovarian cancer risks after risk-reducing salpingectomy at various ages with delayed oophorectomy several years later compared with risk-reducing salpingo-oophorectomy. METHODS: A literature search was performed on cumulative ovarian cancer risks and effects of risk-reducing salpingo-oophorectomy and salpingectomy. Results were used in a modeling study...
Topics
- Adult
- Aged
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genetic Predisposition to Disease
- Humans
- Middle Aged
- Ovarian Neoplasms
- Ovariectomy
- Proportional Hazards Models
