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Article

CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery

29 Jan 2009

Abstract excerpt

Rasmussen encephalitis (RE) is a rare neurological disorder of childhood characterized by uni-hemispheric inflammation, progressive neurological deficits and intractable focal epilepsy. Destruction of neurons and astrocytes by cytotoxic CD8 T cells has been proposed as a pathogenic mechanism underlying this enigmatic disorder. We tested this hypothesis by analysing the clonal composition and T-cell receptor (TCR)...

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PMID: 19179379
DOI: 10.1093/brain/awp003

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