Article

Encephalitis patient derived monoclonal GABA <sub>A</sub> receptor antibodies cause catatonia and epileptic seizures

2021-01-28

Abstract excerpt

Autoantibodies targeting the GABA A receptor (GABA A R) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantibodies and the lack of patient derived monoclonal antibodies (mAbs). We cloned and recombinantly produced five affinity-maturated GABA A R IgG1 mAbs from cerebros...

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Literature Corpus work: fe649d3b-1485-5fc3-a41d-5d5312911164
DOI: 10.1101/2021.01.28.428602

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