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Article

Identification and Characterization of GABAA Receptor Autoantibodies in Autoimmune Encephalitis

11 Jun 2014

Abstract excerpt

Autoimmune forms of encephalitis have been associated with autoantibodies against synaptic cell surface antigens such as NMDA- and AMPA-type glutamate receptors, GABA(B) receptor, and LGI1. However, it remains unclear how many synaptic autoantigens are yet to be defined. Using immunoproteomics, we identified autoantibodies against the GABA(A) receptor in human sera from two patients diagnosed with encephalitis...

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PMID: 24920620
DOI: 10.1523/jneurosci.4415-13.2014

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