Article
Clinicopathologic correlates and natural history of atypical chronic myeloid leukemia.
Cancer - 1 Sept 2021
Montalban-Bravo Guillermo, Kanagal-Shamanna Rashmi, Sasaki Koji, Masarova Lucia, Naqvi Kiran, Jabbour Elias, DiNardo Courtney D, Takahashi Koichi, Konopleva Marina, Pemmaraju Naveen, Kadia Tapan M, Ravandi Farhad, Daver Naval, Borthakur Gautam, Estrov Zeev, Khoury Joseph D, Loghavi Sanam, Soltysiak Kelly A, Pierce Sherry, Bueso-Ramos Carlos, Patel Keyur P, Verstovsek Srdan, Kantarjian Hagop M, Bose Prithviraj, Garcia-Manero Guillermo
Abstract excerpt
BACKGROUND: There are limited data on the clonal mechanisms underlying leukemogenesis, prognostic factors, and optimal therapy for atypical chronic myeloid leukemia (aCML). METHODS: The authors evaluated the clinicopathologic features, outcomes, and responses to therapy of 65 patients with aCML. The median age was 67 years (range, 46-89 years). RESULTS: The most frequently mutated genes included ASXL1 (83%),...
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