Article
Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation.
Science translational medicine - 15 Jan 2020
Wong Wing Hing, Bhatt Sima, Trinkaus Kathryn, Pusic Iskra, Elliott Kevin, Mahajan Nitin, Wan Fei, Switzer Galen E, Confer Dennis L, DiPersio John, Pulsipher Michael A, Shah Nirali N, Sees Jennifer, Bystry Amelia, Blundell Jamie R, Shaw Bronwen E, Druley Todd E
Abstract excerpt
Clonal hematopoiesis is associated with various age-related morbidities. Error-corrected sequencing (ECS) of human blood samples, with a limit of detection of ≥0.0001, has demonstrated that nearly every healthy individual >50 years old harbors rare hematopoietic clones below the detection limit of standard high-throughput sequencing. If these rare mutations confer survival or proliferation advantages, then the...
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