Article
Evaluation of a Liquid Biopsy Protocol using Ultra-Deep Massive Parallel Sequencing for Detecting and Quantifying Circulation Tumor DNA in Colorectal Cancer Patients.
Cancer investigation - 1 Feb 2020
Nguyen Huu Thinh, Tran Duc Huy, Ngo Quoc Dat, Pham Hong-Anh Thi, Tran Thanh-Truong, Tran Vu-Uyen, Pham Truong-Vinh Ngoc, Le Trung Kien, Le Ngoc-An Trinh, Nguyen Ngoc Mai, Vo Binh Thanh, Nguyen Luan Thanh, Nguyen Thien-Chi Van, Bui Quynh Tram Nguyen, Nguyen Huu-Nguyen, Luong Bac An, Le Linh Gia Hoang, Do Duc Minh, Do Thanh-Thuy Thi, Hoang Anh Vu, Dinh Kiet Truong, Phan Minh-Duy, Tran Le Son, Giang Hoa, Nguyen Hoai-Nghia
Abstract excerpt
The identification and quantification of actionable mutations are critical for guiding targeted therapy and monitoring drug response in colorectal cancer. Liquid biopsy (LB) based on plasma cell-free DNA analysis has emerged as a noninvasive approach with many clinical advantages over conventional tissue sampling. Here, we developed a LB protocol using ultra-deep massive parallel sequencing and validated its...
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