Ultra-Deep Sequencing of Plasma-Circulating DNA for the Detection of Tumor- Derived Mutations in Patients with Nonmetastatic Colorectal Cancer.

doi:10.1080/07357907.2021.2017951

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Ultra-Deep Sequencing of Plasma-Circulating DNA for the Detection of Tumor- Derived Mutations in Patients with Nonmetastatic Colorectal Cancer.

Cancer investigation - 1 Apr 2022

Nguyen Huu-Thinh, Luong Bac An, Tran Duc-Huy, Nguyen Trong-Hieu, Ngo Quoc Dat, Le Linh Gia Hoang, Ho Quoc Chuong, Nguyen Hue-Hanh Thi, Nguyen Cao Minh, Tran Vu Uyen, Pham Truong Vinh Ngoc, Le Minh Triet, Le Ngoc An Trinh, Le Trung Kien, Nguyen Thanh Luan, Pham Hong-Anh Thi, Le Hong Thuy, Duong Hong Diep Thi, Hoang Anh Vu, Nguyen Hoang Bac, Truong Dinh Kiet, Phan Minh-Duy, Nguyen Hoai-Nghia, Do Thanh-Thuy Thi, Giang Hoa, Tran Le Son, Tran Diep Tuan

Abstract excerpt

Identification of tumor-derived mutation (TDM) in liquid biopsies (LB), especially in early-stage patients, faces several challenges, including low variant-allele frequencies, interference by white blood cell (WBC)-derived mutations (WDM), benign somatic mutations and tumor heterogeneity. Here, we addressed the above-mentioned challenges in a cohort of 50 nonmetastatic colorectal cancer patients, via a workflow...

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PMID: 34894952
DOI: 10.1080/07357907.2021.2017951

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