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Article

Specific inhibition of Notch1 signaling suppresses properties of lung cancer stem cells

13 Sept 2017

Abstract excerpt

OBJECTIVE: Lung cancer is the leading cause of cancer-related death worldwide with a relatively low 5-year relative survival rate of 16%. Novel and efficient therapeutic approach for lung cancer is desperately needed. MATERIALS AND METHODS: cells by magnetic-assisted cell sorting, then the putative LCSCs were treated with Notch1 inhibitor and Notch1 small interfering RNAs (siRNAs); the growth and proliferation of...

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PMID: 31939436
DOI: 10.4103/jcrt.jcrt_482_17

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