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Article

MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1.

Stem cell research & therapy - 6 May 2020

Zhao Guoli, Zhang Yueying, Zhao Zhonghua, Cai Haibo, Zhao Xiaogang, Yang Tong, Chen Weijun, Yao Chengfang, Wang Zhaopeng, Wang Zhaoxia, Han Chen, Wang Hengxiao

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence and chemo-resistance. Previous studies suggested that miR-153 played essential roles in lung cancer. However, the molecular mechanism of miR-153 in regulating the stemness of non-small cell lung cancer (NSCLC) remains poorly understood. In this study, we investigated the role of miR-153 in regulation of the stemness of...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Identifiers

PMID: 32375892
DOI: 10.1186/s13287-020-01679-7
PMCID: PMC7201619

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