Article
Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and N-acylethanolamines in patients with hereditary angioedema due to FXII mutation.
Allergy - 1 Jan 2025
Ferrara Anne Lise, Palestra Francesco, Piscitelli Fabiana, Petraroli Angelica, Suffritti Chiara, Firinu Davide, López-Lera Alberto, Caballero Teresa, Bork Konrad, Spadaro Giuseppe, Marone Gianni, Di Marzo Vincenzo, Bova Maria, Loffredo Stefania
Abstract excerpt
BACKGROUND: Hereditary angioedema (HAE) is a rare genetic disorder characterized by local, self-limiting edema due to temporary increase in vascular permeability. HAE with normal C1 esterase inhibitor (C1INH) activity includes the form with mutations in the F12 gene encoding for coagulation factor XII (FXII-HAE) causing an overproduction of bradykinin (BK) leading to angioedema attack. BK binding to B2 receptors...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.