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Article

Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment.

Annals of medicine - 1 Jan 2016

Zeerleder Sacha, Levi Marcel

Abstract excerpt

Uncontrolled generation of bradykinin (BK) due to insufficient levels of protease inhibitors controlling contact phase (CP) activation, increased activity of CP proteins, and/or inadequate degradation of BK into inactive peptides increases vascular permeability via BK-receptor 2 (BKR2) and results in subcutaneous and submucosal edema formation. Hereditary and acquired angioedema due to C1-inhibitor deficiency...

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Identifiers

PMID: 27018196
DOI: 10.3109/07853890.2016.1162909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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