Article
Contact System Activation and Bradykinin Generation in Angioedema: Laboratory Assessment and Biomarker Utilization.
Immunology and allergy clinics of North America - 1 Aug 2024
Christiansen Sandra C, Zuraw Bruce L
Abstract excerpt
The role of contact system activation has been clearly established in the pathogenesis of hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH). C1 inhibitor (C1INH)-protease complexes, levels of functional C1INH, plasma kallikrein activation, and cleavage of high-molecular-weight kininogen have each been associated with disease activity. More recently, HAE with normal levels of C1INH (HAE-nl-C1INH)...
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