New insights into hereditary angio-oedema: Molecular diagnosis and therapy.

Abstract excerpt

Hereditary angio-oedema (HAE) is a rare but potentially life-threatening condition. Three types are now recognized. Types I and II HAE involve mutations in the C1NH (SERPING1) gene, encoding the C1 inhibitor protein, whereas type III HAE involves mutations in the F12 gene, encoding coagulation factor XII (Hageman factor). They share a common final pathway leading to increased bradykinin formation. HAE must be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angioedemas, Hereditary
• Share to Angiotensin-Converting Enzyme Inhibitors