Article
Elucidation of the relationships of MET protein expression and gene copy number status with PD-L1 expression and the immune microenvironment in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2020
Yoshimura Katsuhiro, Inoue Yusuke, Tsuchiya Kazuo, Karayama Masato, Yamada Hidetaka, Iwashita Yuji, Kawase Akikazu, Tanahashi Masayuki, Ogawa Hiroshi, Inui Naoki, Funai Kazuhito, Shinmura Kazuya, Niwa Hiroshi, Suda Takafumi, Sugimura Haruhiko
Abstract excerpt
OBJECTIVES: Alterations in the MET gene, such as mutations and high-level amplification, are important drivers of non-small cell lung cancer (NSCLC). The efficacy of immune checkpoint inhibitors (ICIs) in lung cancer with MET abnormalities is unclear. We evaluate the potential relationship between MET alterations and the tumor immune microenvironment and PD-1/PD-L1 axis. MATERIAL AND METHODS: MET and phospho-MET...
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