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Article

PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2018

Sabari J K, Leonardi G C, Shu C A, Umeton R, Montecalvo J, Ni A, Chen R, Dienstag J, Mrad C, Bergagnini I, Lai W V, Offin M, Arbour K C, Plodkowski A J, Halpenny D F, Paik P K, Li B T, Riely G J, Kris M G, Rudin C M, Sholl L M, Nishino M, Hellmann M D, Rekhtman N, Awad M M, Drilon A

Abstract excerpt

Background: MET exon 14 alterations are actionable oncogenic drivers. Durable responses to MET inhibitors are observed in patients with advanced MET exon 14-altered lung cancers in prospective trials. In contrast, the activity of immunotherapy, PD-L1 expression and tumor mutational burden (TMB) of these tumors and are not well characterized. Patients and methods: Patients with MET exon 14-altered lung cancers of...

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Identifiers

PMID: 30165371
DOI: 10.1093/annonc/mdy334
PMCID: PMC6225900

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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