Article
Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
Gastroenterology - 1 May 2020
Masamune Atsushi, Kotani Hiroshi, Sörgel Franziska Lena, Chen Jian-Min, Hamada Shin, Sakaguchi Reiko, Masson Emmanuelle, Nakano Eriko, Kakuta Yoichi, Niihori Tetsuya, Funayama Ryo, Shirota Matsuyuki, Hirano Tatsuya, Kawamoto Tetsuya, Hosokoshi Atsuki, Kume Kiyoshi, Unger Lara, Ewers Maren, Laumen Helmut, Bugert Peter, Mori Masayuki X, Tsvilovskyy Volodymyr, Weißgerber Petra, Kriebs Ulrich, Fecher-Trost Claudia, Freichel Marc, Diakopoulos Kalliope N, Berninger Alexandra, Lesina Marina, Ishii Kentaro, Itoi Takao, Ikeura Tsukasa, Okazaki Kazuichi, Kaune Tom, Rosendahl Jonas, Nagasaki Masao, Uezono Yasuhito, Algül Hana, Nakayama Keiko, Matsubara Yoichi, Aoki Yoko, Férec Claude, Mori Yasuo, Witt Heiko, Shimosegawa Tooru
Abstract excerpt
BACKGROUND & AIMS: Changes in pancreatic calcium levels affect secretion and might be involved in development of chronic pancreatitis (CP). We investigated the association of CP with the transient receptor potential cation channel subfamily V member 6 gene (TRPV6), which encodes a Ca2+-selective ion channel, in an international cohort of patients and in mice. METHODS: We performed whole-exome DNA sequencing from...
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