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Article

Reevaluating the role of TRPV6 deficiency in human and mouse pancreatitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2026

Berke Gergő, Sándor Máté, Raheem Sumiyya, Morales Granda Nataly C, Pesei Zsófia Gabriella, Hegede Réka, Demcsák Alexandra, Németh Balázs Csaba, Witt Heiko, Szentesi Andrea, Hegyi Péter, Rohacs Tibor, Hegyi Eszter, Sahin-Tóth Miklós

Abstract excerpt

Functionally defective genetic variants of the calcium channel transient receptor potential vanilloid type 6 (TRPV6) have been shown to markedly increase the risk for chronic pancreatitis in humans. Genetic inactivation of Trpv6 in mice worsened the severity of pancreatitis induced by secretagogue hyperstimulation. The aims of the present study were to reexamine the role of loss-of-function TRPV6 gene variants in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42412638
DOI: 10.1152/ajpgi.00070.2026
PMCID: PMC13541285

Genes

TRPV6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Reevaluating the role of TRPV6 deficiency in human and mouse pancreatitis.PMID 42412638Read ↗

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