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Article

TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice.

Journal of gastroenterology - 1 Feb 2026

Masamune Atsushi, Masson Emmanuelle, Zou Wen-Bin, Rygiel Agnieszka Magdalena, Chowdhury Sudipta Dhar, Kikuta Kazuhiro, Hayashi Hidehiro, Sasaki Akira, Nakasuji Hitomi, Matsumoto Ryotaro, Takikawa Tetsuya, Xu Yan, Jie Ren, Sekino Yasumasa, Abe Toshiaki, Hatta Waku, Niihori Tetsuya, Aoki Yoko, Sakaguchi Reiko, Mori Yasuo, Rebours Vinciane, Buscail Louis, Wang Yuan-Chen, Kurien Reuben Thomas, Visweswariah Sandhya S, Rosendahl Jonas, Ferec Claude, Oracz Grzegorz, Witt Heiko, Liao Zhuan, Chen Jian-Min, Hamada Shin

Abstract excerpt

BACKGROUND: The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene, encoding a calcium-selective ion channel, was recently identified as a susceptibility gene for pancreatitis. This study aimed to clarify the natural history of TRPV6-related pancreatitis and the impact of pancreas-specific deletion of Trpv6 on pancreatitis in mice. METHODS: Clinical information of the patients carrying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41247519
DOI: 10.1007/s00535-025-02323-y
PMCID: PMC12924865

Genes

TRPV6
PRSS1
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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