Article
Human TRPV6-pathies caused by gene mutations.
Biochimica et biophysica acta. General subjects - 1 Jun 2021
Nett Verena, Erhardt Nicole, Wyatt Amanda, Wissenbach Ulrich
Abstract excerpt
The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for Ca2+ ions. A functional channel is formed by 4 identical subunits [1]. A growing number of mutations are present in human TRPV6 genes which alter channel function and can lead to elevated blood levels of the parathyroid...
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