CLU rs11136000 promotes early cognitive decline in Parkinson's disease.

doi:10.1002/mds.27949

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Article

CLU rs11136000 promotes early cognitive decline in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2020

Sampedro Frederic, Marín-Lahoz Juan, Martínez-Horta Saul, Pérez-González Rocío, Pagonabarraga Javier, Kulisevsky Jaime

Abstract excerpt

BACKGROUND: The C allele of the rs11136000 genetic variant of the clusterin gene has been associated with increased risk of Alzheimer's disease. However, a comprehensive characterization of the role of this genetic variant in early cognitive deterioration in PD is lacking. METHODS: Using the Parkinson's Progression Markers Initiative database, we compared baseline and 5-year cognitive performance between...

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PMID: 31930747
DOI: 10.1002/mds.27949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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