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Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections

21 Apr 2021

Abstract excerpt

C6 deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA) is catalyzed by a family of enzymes known as ADARs (adenosine deaminases acting on RNA) encoded by three genes in mammals. Alternative promoters and splicing produce two ADAR1 proteins, an interferon-inducible cytoplasmic p150 and a constitutively expressed p110 that like ADAR2 is a nuclear enzyme. ADAR3 lacks deaminase activity. A-to-I...

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PMID: 33882257
DOI: 10.1146/annurev-virology-091919-065320

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