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Article

The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2012

Qin C, Cao Q, Ju X, Wang M, Meng X, Zhu J, Yan F, Li P, Ding Q, Chen J, Gu M, Zhang W, Yin C, Zhang Z

Abstract excerpt

BACKGROUND: The von Hippel-Lindau (VHL) tumor suppressor gene and hypoxia-inducible factor-1α (HIF1A) play a pivotal role in renal carcinogenesis. This study was aimed to clarify the influence of VHL and HIF1A polymorphisms on renal cell cancer (RCC) susceptibility and survival. SUBJECTS AND METHODS: We genotyped four potentially functional single-nucleotide polymorphisms (rs779805 in VHL and rs11549465,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell
Share to Genetic Association Studies
Share to Hypoxia-Inducible Factor 1, alpha Subunit
Share to Kaplan-Meier Estimate
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Share to Proportional Hazards Models
Share to Von Hippel-Lindau Tumor Suppressor Protein

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Identifiers

PMID: 21778301
DOI: 10.1093/annonc/mdr325

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma.PMID 21778301Read ↗

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