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Article

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.

Nature communications - 10 Jan 2020

Laukoter Susanne, Beattie Robert, Pauler Florian M, Amberg Nicole, Nakayama Keiichi I, Hippenmeyer Simon

Abstract excerpt

The cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex development. How Cdkn1c regulates corticogenesis is however not clear. To this end we employ Mosaic Analysis with Double Markers (MADM) technology to genetically dissect Cdkn1c gene function in corticogenesis at single cell resolution. We find that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31924768
DOI: 10.1038/s41467-019-14077-2
PMCID: PMC6954230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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