Article
In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression.
Cerebral cortex (New York, N.Y. : 1991) - 1 Mar 2017
Bouschet Tristan, Dubois Emeric, Reynès Christelle, Kota Satya K, Rialle Stéphanie, Maupetit-Méhouas Stéphanie, Pezet Mikael, Le Digarcher Anne, Nidelet Sabine, Demolombe Vincent, Cavelier Patricia, Meusnier Céline, Maurizy Chloé, Sabatier Robert, Feil Robert, Arnaud Philippe, Journot Laurent, Varrault Annie
Abstract excerpt
In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for cortical therapy. It is unknown to which extent epigenetic mechanisms crucial for cortex development and function, such as parental genomic imprinting, are recapitulated by in vitro corticogenesis. Here, using genome-wide transcriptomic and methylation analyses on hybrid mouse tissues...
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