Article

Analysis of CDKN1C in fetal growth restriction and pregnancy loss

2019-01-23

Abstract excerpt

<ns3:p> <ns3:bold>Background:</ns3:bold> Cyclin-dependent kinase inhibitor 1C (CDKN1C) is a key negative regulator of cell growth encoded by a paternally imprinted/maternally expressed gene in humans. Loss-of-function variants in <ns3:italic>CDKN1C</ns3:italic> are associated with an overgrowth condition (Beckwith-Wiedemann Syndrome) whereas “gain-of-function” variants in <ns3:italic>CDKN1C</ns3:italic> that incre...

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Literature Corpus work: da9006a8-9313-5178-a854-601a430cc480
DOI: 10.12688/f1000research.15016.1

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