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Article

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship.

Cancer letters - 28 Jan 2018

Netea-Maier Romana T, Smit Johannes W A, Netea Mihai G

Abstract excerpt

In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric oxide, reactive oxygen species, prostaglandins and other byproducts of arachidonic acid metabolism...

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Identifiers

PMID: 29111350
DOI: 10.1016/j.canlet.2017.10.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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