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Article

Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan.

European journal of sport science - 1 Feb 2023

Alvarez-Romero Javier, Laguette Mary-Jessica N, Seale Kirsten, Jacques Macsue, Voisin Sarah, Hiam Danielle, Feller Julian A, Tirosh Oren, Miyamoto-Mikami Eri, Kumagai Hiroshi, Kikuchi Naoki, Kamiya Nobuhiro, Fuku Noriyuki, Collins Malcolm, September Alison V, Eynon Nir

Abstract excerpt

Previous small-scale studies have shown an association between the COL5A1 gene and anterior cruciate ligament (ACL) injury risk. In this larger study, the genotype and allele frequency distributions of the COL5A1 rs12722 C/T and rs10628678 AGGG/deletion (AGGG/-) indel variants were compared between participants: (i) with ACL injury in independent and combined cohorts from South-Africa (SA) and Australia (AUS) vs...

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PMID: 34821541
DOI: 10.1080/17461391.2021.2011426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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