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Article

The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.

Nucleic acids research - 22 Feb 2021

Wang Lili, Zhan Li, Zhao Yan, Huang Yongchi, Wu Chong, Pan Ting, Qin Qi, Xu Yiren, Deng Zhiping, Li Jing, Hu Honghong, Xue Shaowu, Yan Shunping

Abstract excerpt

DNA damage response is a fundamental mechanism to maintain genome stability. The ATR-WEE1 kinase module plays a central role in response to replication stress. Although the ATR-WEE1 pathway has been well studied in yeasts and animals, how ATR-WEE1 functions in plants remains unclear. Through a genetic screen for suppressors of the Arabidopsis atr mutant, we found that loss of function of PRL1, a core subunit of...

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PMID: 33450002
DOI: 10.1093/nar/gkaa1082
PMCID: PMC7897505

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