Article
Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2020
Heskett Michael B, Sanborn John Z, Boniface Christopher, Goode Benjamin, Chapman Jocelyn, Garg Karuna, Rabban Joseph T, Zaloudek Charles, Benz Stephen C, Spellman Paul T, Solomon David A, Cho Raymond J
Abstract excerpt
Immature teratoma is a subtype of malignant germ cell tumor of the ovary that occurs most commonly in the first three decades of life, frequently with bilateral ovarian disease. Despite being the second most common malignant germ cell tumor of the ovary, little is known about its genetic underpinnings. Here we performed multiregion whole-exome sequencing to interrogate the genetic zygosity, clonal relationship,...
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