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Article

Genomic profiling of meiotic errors and early malignant transformation events in ovarian mature teratoma.

Reproduction (Cambridge, England) - 15 Mar 2026

Takahashi Kotaro, Tamura Ryo, Suda Kazuaki, Yachida Nozomi, Yamaguchi Manako, Mathew Rose Maria, Okuda Shujiro, Yoshihara Kosuke, Nakaoka Hirofumi

Abstract excerpt

Ovarian mature teratoma (OMT) exhibits copy-neutral loss of heterozygosity (CN-LOH) derived from meiotic errors. Studies have classified OMT into five types using these CN-LOH patterns. However, tumor purity issues have hindered accurate classification and molecular characterization. Moreover, the relationship between OMT genomic abnormalities and malignant transformation remains unclear. Here, we used laser...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41863841
DOI: 10.1093/reprod/xaaf019

Genes

PIK3CA
TP53

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