Article
Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria.
Malaria journal - 6 Jan 2020
Ajibaye Olusola, Osuntoki Akinniyi A, Balogun Emmanuel O, Olukosi Yetunde A, Iwalokun Bamidele A, Oyebola Kolapo M, Hikosaka Kenji, Watanabe Yoh-Ichi, Ebiloma Godwin U, Kita Kiyoshi, Amambua-Ngwa Alfred
Abstract excerpt
BACKGROUND: Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and strain-specificity in previously studied antigens. New vaccine candidates are therefore urgently needed. Highly conserved Plasmodium falciparum reticulocyte-binding protein homologue-5 (PfRH5) has been identified as a potential candidate for anti-disease...
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