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Article

Host genetic factors modulating dengue virus: a systematic review of TLR polymorphisms.

BMC infectious diseases - 27 Jan 2026

Candrasari Damiana Sapta, Purwosatrio Petrus Gandi, Purnomosari Dewajani, Laksanawati Ida Safitri, Nirwati Hera

Abstract excerpt

BACKGROUND: Dengue virus (DENV) infection is a substantial global public health burden, affecting ~ 390 million people every year, with a mortality rate of ~ 2.5% of those requiring hospitalization. Despite implementing vaccination and outbreak controls, DENV infection incidence continues to rise, particularly in endemic tropical and subtropical regions. Toll-like receptors (TLRs), as key components of the innate...

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Share to Dengue
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 41593523
DOI: 10.1186/s12879-026-12583-5
PMCID: PMC12917963

Genes

TLR4
TLR3
TLR7
TLR9
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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