Article
Mutation in the VP2 gene of P1-2A capsid protein increases the thermostability of virus-like particles of foot-and-mouth disease virus serotype O.
Applied microbiology and biotechnology - 1 Oct 2018
Ganji Vishweshwar Kumar, Biswal Jitendra K, Lalzampuia H, Basagoudanavar S H, Saravanan P, Tamil Selvan R P, Umapathi V, Reddy G R, Sanyal Aniket, Dechamma H J
Abstract excerpt
Foot-and-mouth disease (FMD) is an economically important, global disease of cloven-hoofed animals. The conventional vaccine could bring down the incidence of disease in many parts of the world but has many limitations and in India, the disease is enzootic. More promisingly, the alternate vaccine candidates, virus-like particles (VLPs) are as immunogenic as a native virus but are more labile to heat than the live...
Topics
- Animals
- Antibodies, Viral
- Capsid Proteins
- Foot-and-Mouth Disease
- Foot-and-Mouth Disease Virus
- Guinea Pigs
- Hot Temperature
- Humans
- Mutation
- Serogroup