Article
SorCS2 facilitates release of endostatin from astrocytes and controls post‐stroke angiogenesis
3 Jan 2020
Abstract excerpt
SorCS2 is an intracellular sorting receptor of the VPS10P domain receptor gene family recently implicated in oxidative stress response. Here, we interrogated the relevance of stress-related activities of SorCS2 in the brain by exploring its role in ischemic stroke in mouse models and in patients. Although primarily seen in neurons in the healthy brain, expression of SorCS2 was massively induced in astrocytes...
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