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Article

Diverse Functions of Parkin in Midbrain Dopaminergic Neurons.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2024

Song Pingping, Krainc Dimitri

Abstract excerpt

Parkinson's disease (PD) is characterized by preferential degeneration of midbrain dopaminergic neurons that contributes to its typical clinical manifestation. Mutations in the parkin gene (PARK2) represent a relatively common genetic cause of early onset PD. Parkin has been implicated in PINK1-dependent mitochondrial quantity control by targeting dysfunctional mitochondria to lysosomes via mitophagy. Recent...

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Identifiers

PMID: 38858837
DOI: 10.1002/mds.29890
PMCID: PMC11341252

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