Article
Superoxide imbalance triggered by Val16Ala-SOD2 polymorphism increases the risk of depression and self-reported psychological stress in free-living elderly people.
Molecular genetics & genomic medicine - 1 Feb 2020
da Cruz Jung Ivo Emilio, da Cruz Ivana Beatrice Mânica, Barbisan Fernanda, Trott Alexis, Houenou Lucien J, Osmarin Turra Bárbara, Duarte Thiago, de Souza Praia Raquel, Maia-Ribeiro Ednea Aguiar, da Costa Escobar Piccoli Jaqueline, Bica Claudia Giugliano, Duarte Marta Maria Medeiros Frescura
Abstract excerpt
BACKGROUND: Oxidative stress and chronic inflammatory states triggered by a single-nucleotide polymorphism (SNP) in superoxide dismutase manganese-dependent gene (Val16Ala-SOD2) have been associated with the risk of developing several chronic, nontransmissible diseases. However, it is still not clear whether the VV-SOD2 genotype that causes higher basal superoxide anion levels has any impact on the risk for...
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