The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism.

doi:10.1007/s10522-015-9561-4

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The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism.

Biogerontology - 1 Oct 2015

Capeleto Dianni, Barbisan Fernanda, Azzolin Verônica, Dornelles Eduardo Bortoluzzi, Rogalski Felipe, Teixeira Cibele Ferreira, Machado Alencar Kolinski, Cadoná Francine Carla, da Silva Tális, Duarte Thiago, Duarte Marta Maria Medeiros Frescura, da Cruz Ivana Beatrice Mânica

Abstract excerpt

Resveratrol is an molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this compound. In humans, a single nucleotide polymorphism (SNP) is present in the enzyme manganese superoxide dismutase (SOD2), localized in codon 16 (rs4880), which can either be an alanine (A) or valine (V). This SNP...

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PMID: 25753816
DOI: 10.1007/s10522-015-9561-4

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