Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor-α and Caspases Pathways.

doi:10.1016/j.jstrokecerebrovasdis.2018.06.032

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Article

Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor-α and Caspases Pathways.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Nov 2018

Pascotini Mr Eduardo Tanuri, Flores Dr Ariane Ethur, Kegler Mrs Aline, Konzen Mrs Vivana, Fornari Mrs Ana Letícia, Arend Mrs Josi, Gabbi Mrs Patricia, Gobo Mrs Luciana Assis, Bochi Dr Guilherme Vargas, Prado Dr Ana Lucia Cervi, de Carvalho Dr Leandro Machado, Duarte Dr Marta M M F, da Cruz Dr Ivana B M, Moresco Dr Rafael Noal, Dos Santos Dr Adair Roberto Soares, Royes Dr Luiz Fernando Freire, Fighera Dr Michele Rechia

Abstract excerpt

The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of vascular diseases. Brain-Derived Neurotrophic Factor (BDNF) plays an essential role in the plasticity and neuronal regeneration of the brain after vascular injuries. However, little is known about interaction between MnSOD Ala16Val SNP on stroke, a frequent neurologic...

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PMID: 30150066
DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.032

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