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Centrosome clustering control in osteoclasts through CCR5-mediated signaling

27 Nov 2023

Abstract excerpt

Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface. However, the regulatory mechanisms and pathophysiological relevance of these processes remain largely unexplored. Bone histomorphometric analyses in Ccr5-deficient mice showed abnormalities in the morphology and...

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PMID: 38012303
DOI: 10.1038/s41598-023-48140-2

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