Article
Immunohistochemical assessment of HRAS Q61R mutations in breast adenomyoepitheliomas.
Histopathology - 1 May 2020
Pareja Fresia, Toss Michael S, Geyer Felipe C, da Silva Edaise M, Vahdatinia Mahsa, Sebastiao Ana Paula M, Selenica Pier, Szatrowski Austin, Edelweiss Marcia, Wen Hannah Y, Mihai Raluca, Varga Zsuzsanna, Foschini Maria P, Rubin Brian P, Ellis Ian O, Chandarlapaty Sarat, Jungbluth Achim A, Brogi Edi, Weigelt Britta, Reis-Filho Jorge S, Rakha Emad A
Abstract excerpt
AIMS: Breast adenomyoepitheliomas (AMEs) are uncommon tumours. Most oestrogen receptor (ER)-positive AMEs have mutations in phosphoinositide 3-kinase (PI3K) pathway genes, whereas ER-negative AMEs usually harbour concurrent mutations affecting the HRAS Q61 hotspot and PI3K pathway genes. Here, we sought to determine the sensitivity and specificity of RAS Q61R immunohistochemical (IHC) analysis for detection of...
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