Article
The Diagnostic Utility of RAS Q61R Mutation-specific Immunohistochemistry in Epithelial-Myoepithelial Carcinoma.
The American journal of surgical pathology - 1 Jul 2021
Nakaguro Masato, Tanigawa Maki, Hirai Hideaki, Yamamoto Yoshinari, Urano Makoto, Takahashi Reisuke H, Sukeda Aoi, Okumura Yuki, Honda Shogo, Tasaki Koichiro, Shimizu Akira, Tsukahara Kiyoaki, Tada Yuichiro, Matsubayashi Jun, Faquin William C, Sadow Peter M, Nagao Toshitaka
Abstract excerpt
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland cancer characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety and overlap of histologic features with other salivary gland tumors, there are broad differential diagnoses. The HRAS Q61R mutation has been reported to be frequent in and specific to EMC. We evaluated...
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