Article
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations.
The Journal of pathology - 1 Apr 2016
Guerini-Rocco Elena, Piscuoglio Salvatore, Ng Charlotte K Y, Geyer Felipe C, De Filippo Maria R, Eberle Carey A, Akram Muzaffar, Fusco Nicola, Ichihara Shu, Sakr Rita A, Yatabe Yasushi, Vincent-Salomon Anne, Rakha Emad A, Ellis Ian O, Wen Y Hannah, Weigelt Britta, Schnitt Stuart J, Reis-Filho Jorge S
Abstract excerpt
Microglandular adenosis (MGA) is a rare proliferative lesion of the breast composed of small glands lacking myoepithelial cells and lined by S100-positive, oestrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative epithelial cells. There is evidence to suggest that MGA may constitute a non-obligate precursor of triple-negative breast cancer (TNBC). We sought to define the genomic...
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